Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients (2025)

1. Law MR, Wald MJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower the risk of ischaemic heart disease?BMJ. 1994; 308: 367–373.

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   Health Applications of Soy Protein Hydrolysates

   PubMed CAS Google Scholar

2. Baigent C, Keech A, Kearney PM, et al, Cholesterol Treatment Trialists’ (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.Lancet. 2005; 366: 1267–1278.

   Article PubMed CAS Google Scholar

3. Ramsay IE, Yeo WW, Jackson PR. Dietary reduction of serum cholesterol concentration: time to think again.BMJ. 1991; 303: 953–957.

   PubMed CAS Google Scholar

4. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids.N Engl J Med. 1995; 333: 276–282.

   Article PubMed CAS Google Scholar

5. Baum JA, Teng H, Erdman JW, et al. Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women.Am J Clin Nutr. 1998; 68: 545–551.

   PubMed CAS Google Scholar

6. Wong WW, Smith EOB, Stuff JE, Hachey DL, Heird WC, Pownell HJ. Cholesterol-lowering effect of soy protein in normocholesterolemic and hypercholesterolemic men.Am J Clin Nutr. 1998; 68(suppl): 1385S-1389S.

   PubMed CAS Google Scholar

7. Crouse JR, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins.Arch Intern Med. 1999; 159: 2070–2076.

   Article PubMed CAS Google Scholar

8. Washburn S, Burke GL, Morgan T, Anthony M. Effects of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women.Menopause. 1999; 6: 7–13.

   Article PubMed CAS Google Scholar

9. Merz-Demlow BE, Duncan AM, Wangen KE, et al. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women.Am J Clin Nutr. 2000; 71: 1462–1469.

   PubMed CAS Google Scholar

10. Teixeira SR, Potter SM, Weigel R, Hannum S, Erdman JW, Hassler CM. Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men.Am J Clin Nutr. 2000; 71: 1077–1084.

    PubMed CAS Google Scholar

11. Hermansen K, Sondergaard M, Hoie L, Carstensen M, Brock B. Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects.Diabetes Care. 2001; 24: 228–233.

    Article PubMed CAS Google Scholar

12. Puska P, Korpelainen V, Hoie LH, Sksovlund E, Lahti E, Smerud KT. Soy in hypercholesterolaemia: a double-blind, placebo-controlled trial.Eur J Clin Nutr. 2002; 56: 352–357.

    Article PubMed CAS Google Scholar

13. Tonstad S, Smerud KT, Hoie L. A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects.Am J Clin Nutr. 2002; 76: 78–84.

    PubMed CAS Google Scholar

14. Dewailley P, Moulin S, Rouget JP, Sezille G, Jaillard J. Effects of polyenylphosphatidyl choline on lipoproteins in patients with hypercholesterolemia.Med Welt. 1985; 36: 367–369.

    Google Scholar

15. Kirsten R, Heintz B, Nelson K, et al. Polyenylphosphatidylcholine improves the lipoprotein profile in diabetic patients.Int J Clin Pharmacol Ther. 1994; 32: 53–56.

    PubMed CAS Google Scholar

16. Lo GS, Goldberg AP, Lim A, Grundhauser JJ, Anderson C, Schonfeld G. Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects.Atherosclerosis. 1986; 62: 239–248.

    Article PubMed CAS Google Scholar

17. Ovesen L, Ebbesen K, Olesen E. The effects of oral soybean phospholipid on serum total cholesterol, plasma triglyceride, and serum high-density lipoprotein cholesterol concentrations in hyperlipidemia.J Parenter Enter Nutr. 1985; 9: 716–719.

    CAS Google Scholar

18. Sirtori CR, Zucchi-Dentone C, Sirtori M, et al. Cholesterol-lowering and HDL-raising properties of lecithinated soy proteins in type II hyperlipidemic patients.Ann Nutr Metab. 1985; 29: 348–357.

    Article PubMed CAS Google Scholar

19. Wangen KE, Duncan AM, Xu X, Kurzer MS. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women.Am J Clin Nutr. 2000; 73: 225–231.

    Google Scholar

20. Lovati MR, Manzoni C, Canavesi A, et al. Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients.J Clin Invest. 1987; 80: 1498–1502.

    Article PubMed CAS Google Scholar

21. Lovati MR, Manzoni C, Corsini A, et al. Low density lipoprotein receptor activity is modulated by soybean globulins in cell culture.J Nutr. 1992; 122: 1971–1978.

    PubMed CAS Google Scholar

22. Lovati MR, Manzoni C, Gianazza E, Sirtori CR. Soybean protein products as regulators of liver low-density lipoprotein receptors. I. Identification of active beta-conglycinin subunits.J Agr Food Chem. 1998; 46: 2474–2480.

    Article CAS Google Scholar

23. Lovati MR, Manzoni C, Gianazza E, et al. Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells.J Nutr. 2000; 130: 2543–2549.

    PubMed CAS Google Scholar

24. Manzoni C, Lovati MR, Gianazza E, Morita Y, Sirtori CR. Soybean protein products as regulators of liver low-density lipoprotein receptors. II. Alpha prime rich commercial soy concentrate and alpha prime deficient mutant differently affect low-density lipoprotein receptor activity.J Agr Food Chem. 1998; 46: 2481–2484.

    Article CAS Google Scholar

25. Sirtori CR, Lovati MR, Manzoni C, et al. Reductions of serum cholesterol by soy proteins: clinical experience and potential molecular mechanism.Nutr Metab Cardiovasc Dis. 1998; 8: 334–340.

    CAS Google Scholar

26. Gianazza E, Eberini I, Arnoldi A, Wait R, Sirtori CR. A proteomic investigation of isolated soy proteins with variable effects in experimental and clinical studies.J Nutr. 2003; 133: 9–14.

    PubMed CAS Google Scholar

27. Wood D, de Backer G, Faergeman O, Graham I, Mancia G, Pyörälä K. Prevention of coronary heart disease in clinical practice. Summary of Recommendations of the Second Task Force of European and Other Societies on Coronary Prevention.Eur Heart J. 1998; 19: 1434–1503.

    Article Google Scholar

28. Damasceno NR, Gidlund MA, Goto H, Dias CT, Okawabata FS, Abdalla DS. Casein and soy protein isolate in experimental atherosclerosis: influence on hyperlipidemia and lipoprotein oxidation.Ann Nutr Metab. 2001; 45: 38–46.

    Article PubMed CAS Google Scholar

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