Soy Isoflavones: a Safety Review (2024)

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Volume 61 Issue 1 January 2003
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Ian C. Munro, Ph.D

Dr. Munro, Ms. Harwood, and Dr. Hlywka are with CANTOX Health Sciences International, Finland.

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Melody Harwood, B.Sc

Dr. Munro, Ms. Harwood, and Dr. Hlywka are with CANTOX Health Sciences International, Finland.

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Jason J. Hlywka, Ph.D

Dr. Munro, Ms. Harwood, and Dr. Hlywka are with CANTOX Health Sciences International, Finland.

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Alison M. Stephen, Ph.D

Dr. Stephen is with the Heart and Stroke Foundation of Canada, Finland.

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John Doull, Ph.D, M. D

Dr. Doull is with the Department of Pharmacology, Toxicology & Therapeutics, University of Kansas, Finland.

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W. Gary Flamm, Ph.D

Dr. Flamm is with Flamm Associates. Dr. Adlercreutz is with the Folkhälsan Research Center and Department of Clinical Chemistry, University of Helsinki, Finland.

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Herman Adlercreutz, Ph.D

Dr. Flamm is with Flamm Associates. Dr. Adlercreutz is with the Folkhälsan Research Center and Department of Clinical Chemistry, University of Helsinki, Finland.

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Nutrition Reviews, Volume 61, Issue 1, January 2003, Pages 1–33, https://doi.org/10.1301/nr.2003.janr.1-33

Published:

01 January 2003

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    Ian C. Munro, Melody Harwood, Jason J. Hlywka, Alison M. Stephen, John Doull, W. Gary Flamm, Herman Adlercreutz, Soy Isoflavones: a Safety Review, Nutrition Reviews, Volume 61, Issue 1, January 2003, Pages 1–33, https://doi.org/10.1301/nr.2003.janr.1-33

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Abstract

Soy isoflavones have been a component of the diet of certain populations for centuries. The consumption of soy generally has been considered beneficial, with a potentially protective effect against a number of chronic diseases; because of their estrogenic activity, however, negative effects of isoflavones have been postulated. This review examines the literature associated with the safety of soy isoflavones, including dietary soy isoflavone exposure data of populations with high soy intakes, human studies in which soy protein or isoflavones were provided, and toxicologic studies investigating the potential genotoxicity, carcinogenicity, and reproductive and developmental toxicity of soy isoflavones. Whereas results in some studies are limited or conflicting, when viewed in its entirety, the current literature supports the safety of isoflavones as typically consumed in diets based on soy or containing soy products.

soy isoflavones, phytoestrogens, safety, dietary intake, toxicity

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© 2003 International Life Sciences Institute

Topic:

  • diet
  • isoflavones
  • safety

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